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This last observation is of particular interest, since it suggests that the relationship between insulin sensitivity and circulating zonulin might be mediated through the obesity-related circulating IL-6 increase, a cytokine that regulates zonulin expression by interacting with its gene promoters through STAT 3 activation (13)

Tyrosine phosphorylated occludin could delocalize/disassemble from the tight junctions and undergo proteasome-mediated degradation, a phenomenon observed in patients suffering from inflammatory bowel syndrome 79,80