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Recently, the increased level of plasma TMAO has been reported to contribute to renal dysfunction and TMAO is reversely correlated with eGFR in the patients with type 2 diabetes

Pro-inflammatory macrophages commonly increase glycolysis and reprogram the TCA cycle and mitochondrial electron transport chain to support rapid cytokine production, reactive oxygen species (ROS) generation, and antimicrobial activity, whereas pro-resolving macrophages more often engage in mitochondrial respiration, fatty acid oxidation, and biosynthetic programs linked to efferocytosis and tissue repair ( Figure 1 )

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Use of selective progesterone receptor modulators and GnRH antagonists Hormonal therapy continues to play a vital role in fibroid management, with new medications expanding options